Η αμερικανική επιχείρηση κατά του Ιράν έχει ήδη περάσει σε μια φάση όπου η αριθμητική αποκτά μεγαλύτερη σημασία από τα πανηγυρικά ...
Νομικά, η ιδρυτική Συνθήκη του Βορείου Ατλαντικού, στο άρθρο 13, επιτρέπει σε κάθε μέλος να αποχωρήσει από την συμμαχία με προειδοποίηση ένα ...
Obesity-associated epigenetic remodeling under androgen deprivation therapy: Implications for cardiometabolic risk in prostate cancer. This is an ASCO Meeting Abstract from the 2026 ASCO Genitourinary ...
Background: Although glycogen synthase kinase-3β (GSK-3β) is mainly localized in the cytosol in cardiomyocytes, mitochondrial GSK-3β has been shown to trigger permeability transition and cell death.
The combination of elraglusib (9-ING-41), a potent small molecule inhibitor of GSK-3β, and gemcitabine and nab-paclitaxel (Abraxane) achieved statistical significance when used for the first-line ...
Autoimmune polyendocrine syndrome type 1 (APS-1) is a life-threatening, autosomal recessive syndrome caused by autoimmune regulator (AIRE) deficiency. In APS-1, self-reactive T cells escape thymic ...
Can γ-secretase modulators stage a comeback? Scientists led by Irene Gerlach at F. Hoffmann-La Roche, Basel, Switzerland, are banking on it. At this year’s CTAD meeting, held October 24-27 in Boston, ...
Introduction: Obesity induces accumulation of lipids in cardiomyocytes, leading to cardiac dysfunction, termed lipotoxic cardiomyopathy. We have shown previously that GSK-3α promotes fatty acid uptake ...
Colorectal cancer (CRC) is one of the most common and lethal types of cancer. Although researchers have made significant efforts to study the mechanisms underlying CRC drug resistance, our knowledge ...
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Background: Recent studies suggest that glycogen synthase kinase (GSK)-3β is involved in the development of major depressive disorder (MDD). The aim of this study was to investigate the interaction ...
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